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Project ENGINE

Suite 0912, Center of Medical Innovation
and Translational Research
2-2, Yamadaoka, Suita,
Osaka 565-0871, Japan
Phone:+81-6-6210-8420
Fax:+81-6-6210-8424
E-mail:
project_engine@me.com

TOP > Introduction

INTRODUCTION


Kiyokazu Nakajima, MD, FACS
Professor & Principal Investigator
For the past few decades, physicians have employed in "minimally invasive treatments," which may provide less operative trauma, less pain, faster recovery, and better cosmesis for patients. Laparoscopic surgery is one of the mainstreams in this field.

Most recently, Natural Orifice Translumenal Endoscopy Surgery (NOTES) was introduced in the United States. It is a totally new surgical technique that a flexible endoscope passes through a natural orifice (mouth, anus, etc.) then through an internal incision in the stomach, vagina or colon, to perform abdominal operations. NOTES has been accepted as the newest frontier in minimally invasive surgery. Performing surgery without any external incisions or scars was advocated as the next major paradigm shift.

During the basic and pre-clinical phase of NOTES, however, researchers have faced numerous difficulties in the use of flexible GI endoscope and its instruments in larger and more complicated peritoneal cavity. As a result, clinical use of NOTES has been still limited in several institutions. Extended research and development need to be conducted.

At Osaka University, we formed a multi-disciplinary team in 2006 and initiated basic research of NOTES. Since early August 2008, we have performed transvaginal NOTES partial gastrectomy for 8 patients with gastric submucosal tumors. Our challenge was highly recognized as not only Japan's first human NOTES series for therapeutic purpose, but also as the world's first partial gastrectomy using NOTES technique. Our patients benefit from NOTES by experiencing virtually “no pain” and rapid recovery after surgery. Yet, throughout the basic and clinical steps, we have encountered numerous technical challenges, where positive integration of flexible GI endoscopy and laparoscopy was considered indispensable.

In the development for therapeutic instruments, diverse and high level of manufacturing skill is necessary along with the knowledge and information from the researchers. If we are going to convert our ideas into a commercial reality, we also need to cooperate with major industries with mature know-how. In 2008, we formed an R & D consortium called “project ENGINE” with domestic industries to develop necessary instruments for this future integration. ENGINE stands for “Endeavor for Next Generation of INterventional Endoscopy.” Currently, this industry-academia collaboration consortium, ENGINE consists of over 20 surgeons and GI doctors from Osaka University and 8 domestic industries.

In this difficult business climate, many industries cannot demonstrate their potentials. Companies around the world are seeking business opportunities to develop and manufacture medical instruments for the next generation treatment as NOTES. With our team of highly motivated doctors towards this future treatment and highly spirited engineers to develop next generation instruments, we truly believe we can bring something out to the world starting out from this ENGINE!!
Kiyokazu Nakajima, MD, FACS
Division of Next Generation Endoscopic Intervention
Global Center for Medical Engineering and Informatics, Osaka University

Department of Surgery, Graduate School of Medicine, Osaka University
[Education]
1992
M.D.     Osaka University Medical School, Osaka, Japan
1999
Ph.D.    Osaka University Graduate School of Medicine, Osaka, Japan
[Post-Graduate Training]
1992 – 1993
Internship, General, Thoracic and Cardiovascular Surgery, Osaka University Hospital, Osaka, Japan
1993 – 1995
Residency, General Surgery, Nissei Hospital, Osaka, Japan
1999 – 2001
Fellowship, Pediatric/Endoscopic Surgery, Osaka University Hospital, Osaka, Japan
2001 – 2003
Postdoctoral Associate in Surgery, Department of Surgery, Weill Medical College of Cornell University, New York, NY, USA
[Working Experience]
1995
Staff Surgeon, General Surgery, Nissay Hospital, Osaka, Japan
1996
Staff Surgeon (Junior), Pediatric Surgery, Osaka University Hospital, Osaka, Japan
1999 - 2001
Staff Surgeon (Senior), Pediatric Surgery, Osaka University Hospital, Osaka, Japan
2001 - 2002
Visiting Fellow in Surgery, Department of Surgery,
Weill Medical College of Cornell University, New York, NY, USA
2002 - 2003
Postdoctoral Associate in Surgery, Department of Surgery,
Weill Medical College of Cornell University, New York, NY, USA
2002 – 2003
Instructor, Minimal Access Surgery Center, New York - Presbyterian Hospital, New York, NY, USA
2003
Assistant Attending Surgeon, Gastroenterological Surgery, Osaka University Hospital, Osaka, Japan
2004 – 2006
Attending Surgeon, General Surgery, Osaka Rosai Hospital, Osaka, Japan
2005 – 2006
Chief, Section of Colon and Rectal Surgery, Osaka Rosai Hospital, Osaka, Japan
2005 –
Vice-Chair, Endoscopic Surgery Training Course, Osaka University Hospital, Osaka, Japan
2005 – 2006
Visiting Lecturer, Department of Surgery Osaka University Graduate School of Medicine, Osaka, Japan
2006 –
Attending Surgeon, Gastroenterological Surgery, Osaka University Hospital, Osaka, Japan
2006 – 2012
Assistant Professor of Surgery, Department of Surgery,
Osaka University Graduate School of Medicine, Osaka, Japan
2010 -
Lecturer, Osaka University Medical School, Osaka, Japan
2012 -
Associate Professor, Department of Surgery,
Osaka University Graduate School of Medicine, Osaka, Japan
2012 -
Professor, Division of Next Generation Endoscopic Intervention
Global Center for Medical Engineering and Informatics, Osaka University, Osaka, Japan
[Licensure and Board Certification]
Physician's License in Japan
Board Certified Surgeon, Japan Surgical Society
Laparoscopic Skill Certification, Japan Society for Endoscopic Surgery
Certified Instructor, Japanese Board of Cancer Therapy
Certified Clinical Educator in Residency Program, Japanese Ministry of Health, Labor and Welfare
Board Certified Surgeon, Japan Society of Gastroenterological Surgery
Board Certified Surgical Oncologist, Japan Society of Gastroenterological Surgery
Board Certified Cancer Therapist, Japanese Board of Cancer Therapy
Board Certified Gastroenterologist, The Japanese Society of Gastroenterology
Board Certified Supervisory Surgeon, Japan Surgical Society
Board Certified Supervisory Surgeon, Japan Society of Gastroenterological Surgery
[Professional Discipline]
1. Digestive surgery
2. Minimally invasive surgery
3. Functional GI diseases and GI motility
4. Inflammatory bowel diseases
5. GI stromal tumors and sarcomas
6. Next generation endoscopic intervention including NOTES
7. Development of new endoscopic instruments/devices
8. Surgical education and training
[Achievements] as of March 31, 2016
Academic publications:
First-author papers (in English)
35
First-author papers (in Japanese)
59
Textbook (in English)
7
Textbook (in Japanese)
13
Academic presentations:
First-author presentation (in English)
96
First-author presentation (in Japanese)
149
Patents:
The total number of applications:99
(including withdrawal, abandoned, PCT applications, etc.)
(9 patents:supported by JST foreign application supporting system)
The number of pending applications:46 (24 patent families)
The number of registrations:13 (US:1, CN:2, JP:10)
Designs:
The total number of applications:14
The number of registrations:14
Trademark:
The total number of applications:2
The number of registrations:2
Grants:
8 major research grants from Ministry of Economy, Trade and Industry
3 research grants from Japanese Society for Promotion of Sciences
19 collaborative research grants from domestic industries/research funds
2 international grants from research funds in USA